Melanoma Framework Data Initiative

Melanoma in Australia represents a major, unsolved public health challenge. It remains one of the leading cancer killers, especially of young and middle-aged adults. This is partly because prognosis remains poor and largely unpredictable for all but early stage disease, and there are essentially no effective treatments for advanced disease.

However, after decades of stagnation, recent therapeutic advances in melanoma seem on the horizon. Recent investigation into the genetic basis of the disease has enabled the discovery of therapeutic agents that specifically target this cancer type. As ultra violet light, the causal agent of melanoma, is such a potent carcinogen this cancer type contains many different mutations. The generation of biomolecular datasets characterising melanoma tumours will aid in the determination of the ‘driver’ mutations behind this disease and aid in the development of further therapeutics.

Genome sequences from a large proportion of the melanoma patient cohort have been generated and will be made available as a public resource to scientists and clinicians.

This Bioplatforms Australia Framework Data Initiative is led by Professor Graham Mann from The University of Sydney in partnership with Queensland Institute of Medical Research, Westmead Millennium Institute, Melanoma Institute Australia, the John Curtin School of Medical Research, Peter MacCallum Cancer Centre (Melbourne Melanoma Project), Ludwig Institute for Cancer Research, Western Australian Institute for Medical Research and Edith Cowan University.

For further information please visit the Bioplatforms Australia Metadata Portal:

Project contacts:

Graham Mann | T: 02 9845 9056 |
Anna Fitzgerald | T: 02 9850 1174 |

Articles and Publications

Melanoma Framework Data Initiative – Nature Publication
Bioplatforms Australia Press Release
May 2017
View Article 

Whole-genome landscapes of major melanoma subtypes
March 2017
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Tumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomes
Molecular Pathology
November 2015
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Australian Melanoma Genome Project Abstract
ICGC meeting, Canada
February 2015
View abstract

Opening the Cellular Black Box of Melanoma
NCI Research Highlights (web media)
August 2015
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Melanoma Genome Project on track
Australian Life Scientist
December 2013
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Melanoma Genome Project on track
October 2013
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Australia project maps melanoma gene
Herald Sun
August 2012
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Melanoma study to aid targeted treatment
The Australian
August 2012
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Researchers begin hunt for melanoma genes
ABC News
August 2012
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Ambitious New Australian Research Program To Defeat Melanoma
Australian Press
August 2012
View press release

Melanoma Genome Project
Research Australia Grassroots
July 2012
View article